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Potassium Carbonate → p-Methoxybenzamidoxime
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 反応物 | 4-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenol | HCID 135750113 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | p-Methoxybenzamidoxime | HCID 21471 | 20% |
反応手順
3-(4-hydroxyphenyl)-5-trifluoromethyl-1,2,4-oxadiazole 13.32 g (0.1 mol) 4-methoxybenzonitrile, 20.85 g (0.3 mol) of hydroxylamine hydrochloride and 41.40 g (0.3 mol) potassium carbonate was added to 400 mL absolute ethanol and refluxed 21 hours. The product was filtered and recrystallized from methanol to give 3.12 g (0.02 mol) of 4-methoxybenzamide oxime.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05567717 |
| 出典データセット | uspto-grants-1996_10 |
| ORD ID | ord-038ef8cc5e154588849257c4b4c199f6 |
| 出典メモ | uspto-grants-1996_10 |