Nimetazepam → Nordiazepam

HRID 865711

反応式

HRID 865711 の反応式
CO[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[NH:13][C:12](=[O:20])[CH2:11][N:10]=2)=[CH:5][CH:4]=1.[N+](C1C=CC2NC(=O)CN=C(C3C=CC=CC=3)C=2C=1)([O-])=O.C(N1C2C=CC=C(C)C=2C=NCC1=O)(C)C.[N+](C1C=CC2N(C)C(=O)CN=C(C3C=CC=CC=3)C=2C=1)([O-])=O.C1(C2C3C=CC=CC=3NC(=O)CN=2)CCCCC1.S1C=CC=C1C1C2C=CC=CC=2NC(=O)CN=1.OC1C=CC(C2N=C(C3C=CC=CC=3)C3C=CC=CC=3NC2=O)=CC=1.[Cl:140]C1C=CC2NC(=O)C(C3C=CC(O)=CC=3)N=C(C3C=CC=CC=3)C=2C=1.COC1C=CC(C2C3C=CC=CC=3NC(=O)C(C3C=CC(O)=CC=3)N=2)=CC=1>>[Cl:140][C:17]1[CH:18]=[CH:19][C:14]2[NH:13][C:12](=[O:20])[CH2:11][N:10]=[C:9]([C:6]3[CH:7]=[CH:8][CH:3]=[CH:4][CH:5]=3)[C:15]=2[CH:16]=1

参加物

10

反応物 9

HCID 4496NimetazepamHCID 4506NitrazepamHCID 151627771,3-dihydro-5-(4-methoxyphenyl)-2H-1,4-benzodiazepin-2-oneHCID 190787311,3-dihydro-3-(4-hydroxyphenyl)-5-phenyl-2H-1,4-benzodiazepin-2-oneHCID 190787391,3-dihydro-5-(4-methoxyphenyl)-3-(4-hydroxyphenyl)-2H-1,4-benzodiazepin-2-oneHCID 190787451,3-dihydro-5-(2-thienyl)-2H-1,4-benzodiazepin-2-oneHCID 190787757-chloro-1,3-dihydro-3-(4-hydroxyphenyl)-5-phenyl-2H-1,4-benzodiazepin-2-oneHCID 190787881,3-dihydro-1-isopropyl-6-methyl-2H-1,4-benzodiazepin-2-oneHCID 1354761245-cyclohexyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

生成物 1

HCID 2997Nordiazepam

実験手順

1,3-dihydro-5-(4-methoxyphenyl)-2H-1,4-benzodiazepin-2-one; 1,3-dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one; 1,3-dihydro-1-isopropyl-6-methyl-2H-1,4-benzodiazepin-2-one; 7-nitro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one; 5-cyclohexyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 1,3-dihydro-5-(2-thienyl)-2H-1,4-benzodiazepin-2-one; 1,3-dihydro-3-(4-hydroxyphenyl)-5-phenyl-2H-1,4-benzodiazepin-2-one; 7-chloro-1,3-dihydro-3-(4-hydroxyphenyl)-5-phenyl-2H-1,4-benzodiazepin-2-one; 1,3-dihydro-5-(4-methoxyphenyl)-3-(4-hydroxyphenyl)-2H-1,4-benzodiazepin-2-one;

出典と根拠

ORDレコード
ord-65ebe607ab504fa395b915dda369c43d
出典データセット
uspto-grants-1996_10
特許番号
US05567391

関連ノート

読み込み中…