Ammonium Hydroxide → 2-Amino-7-nitro-6-trifluoromethoxybenzothiazole
反応式
Cl[C:2]1[S:3][C:4]2[C:10]([N+:11]([O-:13])=[O:12])=[C:9]([O:14][C:15]([F:18])([F:17])[F:16])[CH:8]=[CH:7][C:5]=2[N:6]=1.[OH-].[NH4+:20]>C(O)C>[NH2:20][C:2]1[S:3][C:4]2[C:10]([N+:11]([O-:13])=[O:12])=[C:9]([O:14][C:15]([F:18])([F:17])[F:16])[CH:8]=[CH:7][C:5]=2[N:6]=1参加物
4
反応条件
- 温度
- 110 °C
実験手順
A mixture of 0.4 g of 2-chloro-7-nitro-6-trifluoromethoxybenzothiazole and 10 cm3 of 33% aqueous ammonium hydroxide solution in 30 cm3 of ethanol is heated at 110° C. in an autoclave for 5 hours. The mixture is cooled and the solvent is evaporated off under reduced pressure (2.7 kPa). After purification by flash chromatography on silica with a cyclohexane/ethyl acetate mixture (4/6 by volume) as eluent, 0.22 g of 2-amino-7-nitro-6-trifluoromethoxybenzothiazole is obtained, melting at 180° C.