関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Riluzole | HCID 5070 | — |
| 反応物 | Hydrazine, dihydrochloride | HCID 17548 | — |
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 溶媒 | Ethylene Glycol | HCID 174 | — |
| 生成物 | 2-Hydrazinyl-6-(trifluoromethoxy)-1,3-benzothiazole | HCID 10422158 | 90.3% |
反応手順
To a suspension of 93.6 g of 2-amino-6-trifluoromethoxybenzothiazole in 420 cm3 of ethylene glycol under a stream of nitrogen are added 48 g of hydrazine hydrate and 42 g of hydrazine dihydrochloride. The mixture is heated for 2 hours at 140° C. After cooling, the precipitate is filtered off and triturated with a water/diethyl ether mixture (1/1 by volume). 89.9 g of 2-hydrazino-6-trifluoromethoxybenzothiazole are thus obtained, melting at 208° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05567822 |
|---|
| 出典データセット | uspto-grants-1996_10 |
|---|
| ORD ID | ord-45efd324a5be422a87f5ea1d11e02b26 |
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| 出典メモ | uspto-grants-1996_10 |
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