関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Cyanide | HCID 8929 | — |
| 反応物 | 1-Benzyl-3-(chloromethyl)pyrrolidine | HCID 12364518 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 2-(1-Benzylpyrrolidin-3-yl)acetonitrile | HCID 12364519 | 92% |
反応手順
16.8 g (0.08 mole) (3RS)-1-benzyl-3-chloromethyl pyrrolidine and 5.88 g (0.12 mole) of sodium cyanide was dissolved in 250 ml dimethyl sulfoxide. The mixture was stirred at 60° C. for two days and at room temperature for one week. Water was added and the mixture was extracted three times with ethyl acetate. The combined organic layer was washed with brine, dried (Na2SO4), filtered and evaporated to yield 14.7 g (92%) of the product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05723444 |
|---|
| 出典データセット | uspto-grants-1998_03 |
|---|
| ORD ID | ord-56818a6d757b4766865fa51ce27de994 |
|---|
| 出典メモ | uspto-grants-1998_03 |
|---|
