Ethanol → Ethyl 2-hydroxy-2-phenylpropanoate

HRID 866002

反応式

HRID 866002 の反応式
[C:1]1([C:7]([CH3:12])([OH:11])[C:8]([OH:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(=O)(=O)(O)O.[CH2:18](O)[CH3:19]>CCOCC>[C:1]1([C:7]([CH3:12])([OH:11])[C:8]([O:10][CH2:18][CH3:19])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 1303Atrolactic acid

生成物 1

HCID 6429709Ethyl 2-hydroxy-2-phenylpropanoate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

(±)-Phenyllactic acid (4.96 g) and 1/2 ml concentrated sulfuric acid in 150 ml absolute ethanol is refluxed for 18 hours. Solvent is stripped, the residue is dissolved in ether, and extracted with saturated sodium bicarbonate solution. The ether is dried, filtered, and stripped to leave (±)-ethyl phenyllactate. NMR (CDCl3): δ1.3 (t, 3H), 3.0(d of d, 1H), 3.1 (d of d, 1H), 4.2 (q, 2H), 4.4 (d of d, 1H), 7.3 (m, 5H).

後処理

  1. extractionextracted with saturated sodium bicarbonate solution
  2. dry with materialThe ether is dried
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-4da8ca9e64d34f87bdf406815196a29d
出典データセット
uspto-grants-1996_10
特許番号
US05569674

関連ノート

読み込み中…