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Hydrogen Bromide → 2-(Bromomethyl)-1,3-dimethoxybenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen Bromide | HCID 260 | — |
| 反応物 | Sodium Chloride | HCID 5234 | — |
| 反応物 | (2,6-Dimethoxyphenyl)methanol | HCID 2776839 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 2-(Bromomethyl)-1,3-dimethoxybenzene | HCID 15556958 | — |
反応手順
After a mixture of 5.7 grams (0.034 mole) of 2,6-dimethoxyphenylmethanol in 40 mL of concentrated hydrobromic acid was stirred at ambient temperature for about one hour, the reaction mixture was taken up in diethyl ether. Solid sodium chloride was added to the mixture to obtain a phase separation. The organic layer was separated and concentrated under reduced pressure, yielding about 4.7 grams of 2,6-dimethoxyphenylmethyl bromide. This compound was used immediately in the next reaction.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05569664 |
| 出典データセット | uspto-grants-1996_10 |
| ORD ID | ord-7323ba6f5da0405a87601d1bbdbdb171 |
| 出典メモ | uspto-grants-1996_10 |