化工社化工社 化学情報印刷レポート · 研究参考用
Tetrahydrofuran → 3-Chloro-4-methoxybenzoyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 3-Chloro-p-anisic acid | HCID 169982 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 3-Chloro-4-methoxybenzoyl chloride | HCID 4769299 | — |
反応手順
A stirred solution of 0.22 gram (0.0012 mole) of 3-chloro-4-methoxybenzoic acid in a small amount of tetrahydrofuran and chloroform was cooled to 0° C., and 0.12 mL (0.0014 mole) of oxalyl chloride was added dropwise. Upon completion of addition, the reaction mixture was allowed to warm to ambient temperature, where it was stirred for about 3.5 hours. After this time the reaction mixture was concentrated under reduced pressure, yielding 3-chloro-4-methoxybenzoyl chloride, which was dissolved in a small amount of tetrahydrofuran for later use.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05569664 |
| 出典データセット | uspto-grants-1996_10 |
| ORD ID | ord-ef7b2c9f6f784ede8ceb8024279c9555 |
| 出典メモ | uspto-grants-1996_10 |