Ethyl Acetate → HCID 178509648、化合物

HRID 866278ノート

反応式

HRID 866278 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=2[C:11]#[N:12])[CH:5]=[CH:6][C:7]=1[NH2:8].C(O[CH2:21][CH3:22])(=O)C>C(O)C.[Cl-].[Na+].O>[CH2:21]([C:22]1[NH:8][C:7]2[CH:6]=[CH:5][C:4]([C:9]3[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=3[C:11]#[N:12])=[CH:3][C:2]=2[N:1]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 8857Ethyl AcetateHCID 21468845HCID 21468845、化合物

生成物 1

HCID 178509648HCID 178509648、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 57417360Sodium chloride; water溶媒

実験手順

2-(3,4-Diaminophenyl)benzonitrile (2.4 moles, 0.50 g) was dissolved in 3 ml ethanol. Ethyl phenylacetamidate hydrochloride (2.88 mmoles, 0.573 g) (prepared from HCl gas bubbled through benzyl cyanide and ethanol) was added. The reaction was warmed on a steam bath for 10 minutes. Ethyl acetate and brine were added. The organic phase was separated, dried and concentrated. The product was precipitated from ethyl acetate and hexane and filtered to yield 290 mg of 2-benzyl-5-(2-cyanophenyl)-1H-benzimidazole. (MS)

後処理

  1. temperatureThe reaction was warmed on a steam bath for 10 minutes
  2. customThe organic phase was separated
  3. customdried
  4. concentrationconcentrated
  5. customThe product was precipitated from ethyl acetate and hexane
  6. filtrationfiltered

出典と根拠

ORDレコード
ord-fbf4518337d542f5a85df8952719ae32
出典データセット
uspto-grants-1996_10
特許番号
US05569768

反応ノート

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