Ammonia → 2-Chloro-6-fluorobenzylamine

温度

100 °C

An autoclave was charged with 89.0 g. (0.5 mole) of 2-chloro-6-fluorobenzyl chloride, 170.0 g. (10 mole) ammonia and 50 ml. benzene. The reaction vessel was sealed and the contents heated at 100° C. for 15 hours. The excess ammonia was carefully evaporated off from the cooled contents of the autoclave with a stream of nitrogen. The residue was washed with water, and the organic phase after drying with anhydrous MgSO4, fractionated to afford 72.4 g. (90%) of product as a clear liquid; b.p. 99°-100° C./20 mm; NMR (CDCl3) δ 1.46 (s, 2H); 3.88 (d, 2H); 7.00 (m, 3H).

1. additionAn autoclave was charged with 89.0 g
2. customThe reaction vessel was sealed
3. customThe excess ammonia was carefully evaporated off from the cooled contents of the autoclave with a stream of nitrogen
4. washThe residue was washed with water
5. dry with materialthe organic phase after drying with anhydrous MgSO4
6. customto afford 72.4 g

ORDレコード

ord-d162db78788f4b4f982c0b9e20eafc34

出典データセット

uspto-grants-1978_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04098787