関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Methanesulfonic Acid | HCID 6395 | — |
| 反応物 | N-[[(3,5-dichlorophenyl)amino]carbonyl]glycine | HCID 595293 | — |
| 溶媒 | Chlorobenzene | HCID 7964 | — |
| 生成物 | 3-(3,5-Dichlorophenyl)-2,4-imidazolidinedione | HCID 168691 | 95.3% |
反応手順
To a suspension of 3-(3,5-dichlorophenyl)-ureidoacetic acid (526 g.) in chlorobenzene (2,250 cc.) is added methanesulphonic acid (d = 1.48) (10 cc., representing 0.077 mol per mol of ureidoacetic acid). The water formed in the reaction is removed by azeotropic distillation. After 45 minutes' distillation, a limpid solution is obtained. After cooling to about 15° C, the precipitate formed is filtered off and washed on the filter with ethanol (500 cc.) at 10° C. After drying, 3-(3,5-dichlorophenyl)-hydantoin (467 g.) melting at 199° C is obtained. Yield: 94%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04099008 |
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| 出典データセット | uspto-grants-1978_07 |
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| ORD ID | ord-3c3722fd6f2d44169a5439e24aec2148 |
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| 出典メモ | uspto-grants-1978_07 |
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