関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Benzenesulfonic Acid | HCID 7371 | — |
| 反応物 | N-[[(3,5-dichlorophenyl)amino]carbonyl]glycine | HCID 595293 | — |
| 溶媒 | Chlorobenzene | HCID 7964 | — |
| 生成物 | 3-(3,5-Dichlorophenyl)-2,4-imidazolidinedione | HCID 168691 | 90.6% |
反応手順
To a suspension of 3-(3,5-dichlorophenyl)-ureidoacetic acid (26.3 g.) in chlorobenzene (180 cc.) is added benzenesulphonic acid (1.2 g. representing 0.068 mol per mol of ureidoacetic acid). The water formed in the reaction is removed by azeotropic distillation. After 30 minutes' distillation, a limpid solution is obtained. After cooling to about 15° C, the precipitate formed is filtered off and washed on the filter with ethanol (25 cc.) at 10° C. After drying, 3-(3,5-dichlorophenyl)-hydantoin (22.2 g.) melting at 199° C is obtained. Yield: 90.5%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04099008 |
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| 出典データセット | uspto-grants-1978_07 |
|---|
| ORD ID | ord-c2f494f9b56c4c209ba7eec1f8842a1e |
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| 出典メモ | uspto-grants-1978_07 |
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