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Dimethyl Sulfoxide → Ethanediamide, N1,N2-bis(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethyl Sulfoxide | HCID 679 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | Phthalic Anhydride | HCID 6811 | — |
| 反応物 | Oxalic acid, dihydrazide | HCID 13826 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Ethanediamide, N1,N2-bis(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)- | HCID 113193 | — |
反応手順
Two moles of phthalic anhydride (296 g.) and one mole of oxalic dihydrazide (118 g.) in 500 ml. dimethyl sulfoxide and 750 ml. toluene were heated at reflux until two moles of water were removed (about 2 hours). The mixture was cooled and filtered. After washing with benzene, the white product was dried to constant weight at 50° C giving an essentially quantitative yield of N,N'bis(phthalimido)oxamide #-# dimethyl sulfoxide 1:2 complex.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04100132 |
| 出典データセット | uspto-grants-1978_07 |
| ORD ID | ord-6df4c634f5fb4287861990b6ed1ce0ee |
| 出典メモ | uspto-grants-1978_07 |