Water → HCID 22762753、化合物

HRID 866852ノート

反応式

HRID 866852 の反応式
Cl[CH2:2][C:3]1[O:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)=[CH:6][N:7]=1.[C:15]1(=[O:25])[NH:19][C:18](=[O:20])[C:17]2=[CH:21][CH:22]=[CH:23][CH:24]=[C:16]12.[K].O>CN(C)C=O>[Cl:14][C:11]1[CH:12]=[CH:13][C:8]([C:5]2[O:4][C:3]([CH2:2][N:19]3[C:18](=[O:20])[C:17]4=[CH:21][CH:22]=[CH:23][CH:24]=[C:16]4[C:15]3=[O:25])=[N:7][CH:6]=2)=[CH:9][CH:10]=1

参加物

5

反応物 3

HCID 962WaterHCID 7369662-(Chloromethyl)-5-(4-chlorophenyl)-1,3-oxazoleHCID 24194345Phthalimide potassium salt

生成物 1

HCID 22762753HCID 22762753、化合物収率 71%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A suspension of 2.3 g of 2-chloromethyl-5-(4-chlorophenyl) oxazole and 1.94 g of potassium phthalimide in 15 ml of dimethylformamide was stirred at room temperature for one hour. The reaction mixture was poured into 300 ml of water, and the resultant precipitate was filtered and recrystallized from ethanol to give 2.4 g (71 percent) of N-[5-(4-chlorophenyl)-2-oxazolyl]methylphthalimide.

後処理

  1. filtrationthe resultant precipitate was filtered
  2. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-2c11c45f037d45448040d4a98aeb33bb
出典データセット
uspto-grants-1978_07
特許番号
US04101660

反応ノート

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