Diethyl Ether → 3-Bromo-1-(4-fluorophenyl)-1-phenylpropan-2-one

HRID 866940ノート

反応式

HRID 866940 の反応式
[Br:1]Br.[F:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11](=[O:13])[CH3:12])=[CH:6][CH:5]=1.CCOCC>C(O)(=O)C>[Br:1][CH2:12][C:11](=[O:13])[CH:10]([C:7]1[CH:6]=[CH:5][C:4]([F:3])=[CH:9][CH:8]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 24408BromineHCID 125490341-(4-Fluorophenyl)-1-phenylpropan-2-one

生成物 1

HCID 125490353-Bromo-1-(4-fluorophenyl)-1-phenylpropan-2-one

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

Bromine (14 85g.) in acetic acid (200 ml.) was added dropwise to a solution of 1-p-fluorophenyl-1-phenylpropan-2-one (20 1g.) in acetic acid (200 ml.) at 60° - 70°. After 30 minutes, the reaction mixture was poured on to ice. Isolation through ether in the usual manner gave crude 3-bromo-1-p-fluorophenyl-1-phenyl-propan-2-one (28g.) which was converted by the procedures described in Example 1 to 3-(N-Benzyl,N-methylamino)-1-p-fluorophenyl-1-phenyl-propan-2-ol (38%), m.p. 61° - 62°.

後処理

  1. additionthe reaction mixture was poured on to ice

出典と根拠

ORDレコード
ord-b9c12468bfe2470997d16eb4a7de177f
出典データセット
uspto-grants-1978_07
特許番号
US04101676

反応ノート

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