Dimethylamine → 3-Dimethylamino-1-p-fluorophenyl-1-phenyl-propan-2-one

HRID 866941ノート

反応式

HRID 866941 の反応式
[CH3:1][NH:2][CH3:3].Br[CH2:5][C:6](=[O:21])[CH:7]([C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C(O)C.CCOCC>[CH3:1][N:2]([CH3:3])[CH2:5][C:6](=[O:21])[CH:7]([C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参加物

5

反応物 2

HCID 674DimethylamineHCID 125490353-Bromo-1-(4-fluorophenyl)-1-phenylpropan-2-one

生成物 1

HCID 203090663-Dimethylamino-1-p-fluorophenyl-1-phenyl-propan-2-one

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 3283Diethyl Ether溶媒

実験手順

Dimethylamine in ethanol (30 ml s of 33% solution) was added to a solution of 3-bromo-1-p-fluorophenyl-1-phenylpropan-2-one (13g.) in dry ether. After 45 minutes, the reaction mixture was extracted with dilute hydrochloric acid and ether. Basification of the acid extract and subsequent isolation through ether in the usual manner gave 3-dimethylamino-1-p-fluorophenyl-1-phenyl-propan-2-one isolated as the hydrochloride (5 8g., 53%), m.p. 210° - 220°.

後処理

  1. extractionthe reaction mixture was extracted with dilute hydrochloric acid and ether
  2. extractionBasification of the acid extract

出典と根拠

ORDレコード
ord-d60b0cc9d3134597b44c1c97d182a35a
出典データセット
uspto-grants-1978_07
特許番号
US04101676

反応ノート

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