Dimethylamine → 3-Dimethylamino-1,1-diphenyl-propan-2-ol

HRID 866946ノート

反応式

HRID 866946 の反応式
[C:1]1([CH:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:8]([OH:11])[CH2:9]Br)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:18][NH:19][CH3:20]>C(O)C>[CH3:18][N:19]([CH3:20])[CH2:9][CH:8]([OH:11])[CH:7]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 674DimethylamineHCID 125490671,1-Diphenyl-3-bromopropan-2-ol

生成物 1

HCID 125491223-Dimethylamino-1,1-diphenyl-propan-2-ol収率 75%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1,1-Diphenyl-3-bromopropan-2-ol (500mg.) prepared as described in Example 20 was treated with excess dimethylamine in ethanol and the solution allowed to stand overnight. Solvent was removed by evaporation and the residue dissolved in dilute hydrochloric acid and ether. Basification of the acid extract and isolation through ether in the usual manner gave 3-dimethylamino-1,1-diphenyl-propan-2-ol (330mg, 75%) m.p. 72° - 73°

後処理

  1. customSolvent was removed by evaporation
  2. dissolutionthe residue dissolved in dilute hydrochloric acid
  3. extractionBasification of the acid extract

出典と根拠

ORDレコード
ord-53b55bb22b004e56be03f533f7f4fbff
出典データセット
uspto-grants-1978_07
特許番号
US04101676

反応ノート

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