化工社化工社 化学情報印刷レポート · 研究参考用
Dimethyl Sulfoxide → Amoxicillin Dimethyl Sulfoxide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethyl Sulfoxide | HCID 679 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | Amoxicillin | HCID 33613 | — |
| 反応物 | Amoxicillin Trihydrate | HCID 62883 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Amoxicillin Dimethyl Sulfoxide | HCID 70528119 | — |
反応手順
Fifty grams of amoxicillin trihydrate is added in portions, with stirring, to 375 ml. of dimethyl sulfoxide. The mixture is stirred at room temperature for 2 hours, then diluted with 75 ml. of methylene chloride and cooled to 0°-5°. The solid product is collected by filtration, washed with methylene chloride and dried. Analysis shows 3 moles of dimethyl sulfoxide and 0.5 mole of water for each mole of amoxicillin; formula weight = 609.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04101661 |
| 出典データセット | uspto-grants-1978_07 |
| ORD ID | ord-6a641e2172144ef89d40daebb7862663 |
| 出典メモ | uspto-grants-1978_07 |