化工社化工社 化学情報印刷レポート · 研究参考用
Amantadine → Adamantan-1-yl-[2-(3-thieno[2,3-d]isoxazol-3-yl-phenoxy)-ethyl]-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Amantadine | HCID 2130 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-[3-(2-Bromo-ethoxy)-phenyl]-thieno[2,3-d]isoxazole | HCID 21983582 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Adamantan-1-yl-[2-(3-thieno[2,3-d]isoxazol-3-yl-phenoxy)-ethyl]-amine | HCID 21983590 | — |
反応手順
The title compound is prepared from 3-[3-(2-bromo-ethoxy)-phenyl]-thieno[2,3-d]isoxazole, potassium carbonate, 1-adamantanamine and acetonitrile essentially as described above in example 18 except that the reaction is run overnight and the compound is purified by column chromatography using a graded solvent mixture of 5% ethyl acetate in DCM to 10% methanol in ethyl acetate. Purity by LC/MS (APCI)=97%, [M+H]+=395.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07091199B1 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-fb43606501f3400b8d4cf5f8ac7ab8df |
| 出典メモ | uspto-grants-2006_08 |