Dimethylformamide → Cephalexin ethanol

関与物質

反応手順

A slurry of 47.4 g of cephalexin bis-DMF solvate in 600 ml of 3A ethanol (K.F=0.03%) was stirred at room temperature and seeded with a few milligrams of a product from an earlier like preparation. After stirring the mixture 5 hours at room temperature, the ethanol in the mixture was evaporated until the total weight of the resulting slurry was 230 g. Filtration provided a crystalline cephalexin ethanol solvate. Air drying the product overnight, provided 35.1 g of crystalline desolvated cephalexin ethanolate.

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