Dichloromethane → (trans)-3-Amino-4-ethyl-2-oxo-1-azetidinesulfonic acid

HRID 867653ノート

反応式

HRID 867653 の反応式
C([N+](CCCC)(CCCC)CCCC)CCC.C(OC([NH:25][C@H:26]1[C@H:29]([CH2:30][CH3:31])[N:28]([S:32]([O-:35])(=[O:34])=[O:33])[C:27]1=[O:36])=O)(C)(C)C.ClCCl>C(O)=O>[NH2:25][C@H:26]1[C@H:29]([CH2:30][CH3:31])[N:28]([S:32]([OH:35])(=[O:33])=[O:34])[C:27]1=[O:36]

参加物

4

反応物 2

HCID 6344DichloromethaneHCID 131714274(trans)-3-t-Butoxycarbonylamino-4-ethyl-2-oxo-1-azetidinesulfonic acid, tetrabutylammonium salt

生成物 1

HCID 13575528(trans)-3-Amino-4-ethyl-2-oxo-1-azetidinesulfonic acid収率 34.7%

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

(trans)-3-t-Butoxycarbonylamino-4-ethyl-2-oxo-1-azetidinesulfonic acid, tetrabutylammonium salt (6.75 g) in 40 ml of 98% formic acid is stirred for 3 hours at ambient temperature. Dichloromethane (60 ml) is added and the mixture is refrigerated for about 16 hours. The resulting precipitate is separated by filtration and then dried in vacuo to yield 0.85 g of the title compound, melting point 185° C., dec.

後処理

  1. customThe resulting precipitate is separated by filtration
  2. customdried in vacuo

出典と根拠

ORDレコード
ord-f0bb8e6b1f844640b2388124c3912948
出典データセット
uspto-grants-1988_10
特許番号
US04775670

反応ノート

読み込み中…