Piperidine → HCID 14306131、化合物
反応式
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:7][O:8][CH2:9][C:10]1[N:15]=[C:14](Cl)[CH:13]=[CH:12][N:11]=1>ClCCl>[CH3:7][O:8][CH2:9][C:10]1[N:15]=[C:14]([N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[CH:13]=[CH:12][N:11]=1参加物
4
実験手順
Piperidine (6.17 ml) in dichloromethane (40 ml) was added dropwise to a solution of 2-methoxymethyl-4-chloropyrimidine (4.71 g) in dichloromethane (40 ml). After standing overnight at room temperature the mixture was heated under reflux for 1 hour. After cooling the solution was washed with water, dried and stripped. The residue was chromatographed (silica gel, CHCl3) to give 2-methoxymethyl-4-piperidinopyrimidine (4.49 g) as an oil.
後処理
- temperaturethe mixture was heated
- temperatureunder reflux for 1 hour
- temperatureAfter cooling the solution
- washwas washed with water
- customdried
- customThe residue was chromatographed (silica gel, CHCl3)
出典と根拠
- ORDレコード
- ord-90ebdf45ce7948058a334d63dc3ab216
- 出典データセット
- uspto-grants-1988_10
- 特許番号
- US04777172
反応ノート
読み込み中…