化工社化工社 化学情報印刷レポート · 研究参考用
Water → HCID 178488135、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4-Chloromethyl-5-methyl-6-piperidino pyrimidine hydrochloride | HCID 21245798 | — |
| 反応物 | HCID 178488032 | HCID 178488032 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | HCID 178488135 | HCID 178488135 | — |
反応手順
A mixture of 4-chloromethyl-5-methyl-6-piperidino pyrimidine hydrochloride (4.63 g) and 2-mercapto-5-methoxybenzimidazole (3.18 g) in ethanol (180 ml) were heated at 50° for 5 hours. The solution was stripped to a residual glass, to which water was added, the pH raised to 13 (NaOH), and extracted with chloroform. Extracts were dried (K2CO3) and stripped to a residual glass which crystallised from ethyl acetate to give 5-methoxy-2-(5-methyl-6-piperidino-4-pyrimidinylmethylthio)-(1H)-benzimidazole, 5.67 g, m.p. 94°-96°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04777172 |
| 出典データセット | uspto-grants-1988_10 |
| ORD ID | ord-eb5af92d3ded4a6cb1f81bf16836f9ae |
| 出典メモ | uspto-grants-1988_10 |