Hydrochloric Acid → HCID 21289105、化合物
反応式
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][N:5]([NH:11]C(OC(C)(C)C)=O)[CH2:6]2.[ClH:19]>C(O)(C)C>[ClH:19].[NH2:11][N:5]1[CH2:4][C:3]2[C:7](=[CH:8][CH:9]=[CH:10][C:2]=2[F:1])[CH2:6]1参加物
4
実験手順
3.8 g of 4-fluoro-N-tert.-butoxycarbonylamino-isoindoline are introduced into 30 ml of concentrated hydrochloric acid at room temperature. The mixture is subsequently stirred at room temperature for 1 hour and the solvent is then distuilled off in vacuo. The residue is treated with hot i-propanol; after cooling to 10° C., the precipitate is filtered off with suction. 2.1 g of 2-amino-4-fluoro-isoindoline hydrochloride are obtained.
後処理
- temperatureafter cooling to 10° C.
- filtrationthe precipitate is filtered off with suction
出典と根拠
- ORDレコード
- ord-8a0e96e3985b482da12a2bc3e0dbb008
- 出典データセット
- uspto-grants-1988_10
- 特許番号
- US04777181
反応ノート
読み込み中…