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Water → 2-[5-(4-Bromobutyl)-3-methyl-2-thienyl]-1,3-dioxolane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 1,4-Dibromobutane | HCID 8056 | — |
| 反応物 | 2-(3-Methylthiophen-2-yl)-1,3-dioxolane | HCID 12926522 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | 2-[5-(4-Bromobutyl)-3-methyl-2-thienyl]-1,3-dioxolane | HCID 12926521 | 68.5% |
反応手順
A solution of 2-(3-methyl-2-thienyl)-1,3-dioxolane (12.3 g) in dry tetrahydrofuran (150 ml) was treated with a solution of n-butyl lithium in hexane (1.6M, 50 ml) at -60°, under nitrogen. After 1 h, 1,4-dibromobutane (17.3 g) was added and the mixture was stirred at -50° for 3 h and at room temperature for 18 h. Water (75 ml) was added and the mixture extracted with ether. The organic extract was distilled to give the title compound as a light brown oil (15.1 g) b.p. 250°/0.15 mm.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04777179 |
| 出典データセット | uspto-grants-1988_10 |
| ORD ID | ord-62c86ba913394a188e1014e5cb6d6e07 |
| 出典メモ | uspto-grants-1988_10 |