Ammonia → HCID 19980851、化合物

HRID 867941ノート

反応式

HRID 867941 の反応式
[NH3:1].O=[C:3]([CH3:11])[CH2:4][C:5]([O:7][CH2:8][CH2:9][OH:10])=[O:6]>C(O)C>[NH2:1]/[C:3](/[CH3:11])=[CH:4]\[C:5]([O:7][CH2:8][CH2:9][OH:10])=[O:6]

参加物

4

反応物 2

HCID 222AmmoniaHCID 118544Butanoic acid, 3-oxo-, 2-hydroxyethyl ester

生成物 1

HCID 19980851HCID 19980851、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Anhydrous ammonia gas was bubbled through a solution of 2-hydroxyethyl 3-oxo-butyrate (25 g, 0.17 moles) (ref 5) and ethanol (250 mL) for 20 minutes. This solution was stirred for 16 hours at room temperature. The solvent was removed in vacuo and the resulting oil was chromatographed on silica gel (250 g) using etyl acetate-hexane 60:40 as eluant. The enriched fractions were combined and the solvent removed in vacuo to give the product; H' NMR CDCl3 4.33 (t, 2H) 3.85 (t, 2H) 3.55 (s, 1H) 2.85 (broad singlet, 1H) 2.31 (s, 3H).

後処理

  1. customThe solvent was removed in vacuo
  2. customthe resulting oil was chromatographed on silica gel (250 g)
  3. customthe solvent removed in vacuo
  4. customto give the product

出典と根拠

ORDレコード
ord-fe2403b9755f4cf5b8c3991761bf7c55
出典データセット
uspto-grants-1988_10
特許番号
US04777167

反応ノート

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