化工社化工社 化学情報印刷レポート · 研究参考用
Formic Acid → 6-amino-5-formamido-1-propyl-2,4-(1H,3H)-pyrimidinedione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formic Acid | HCID 284 | — |
| 反応物 | 6-Amino-1-propyluracil | HCID 104562 | — |
| 反応物 | Sodium Nitrite | HCID 23668193 | — |
| 触媒 | Platinum | HCID 23939 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 6-amino-5-formamido-1-propyl-2,4-(1H,3H)-pyrimidinedione | HCID 15931310 | — |
反応手順
Sodium nitrite (127 kg) was dissolved in water and added to suspension of 6-amino-1-propyl-2,4-(1H,3H)-pyrimidinedione (300 kg) in formic acid (1 400 kg). Pt/C 5 % was added and the reaction mixture was heated to 40°-80° C. The catalyst was filtered off, formic acid was distilled off and ethanol (870 kg) was added. The product was precipitated by cooling and isolated by centrifugation, washed with ethanol/water and used directly in Example 2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04777255 |
| 出典データセット | uspto-grants-1988_10 |
| ORD ID | ord-c989df1d00ac4daeaf6f9d8b1d9d8be3 |
| 出典メモ | uspto-grants-1988_10 |