Formic Acid → 6-amino-5-formamido-1-propyl-2,4-(1H,3H)-pyrimidinedione

HRID 867945

反応式

HRID 867945 の反応式
[N:1]([O-])=O.[Na+].[NH2:5][C:6]1[N:11]([CH2:12][CH2:13][CH3:14])[C:10](=[O:15])[NH:9][C:8](=[O:16])[CH:7]=1.[CH:17]([OH:19])=O>O.[Pt]>[NH2:5][C:6]1[N:11]([CH2:12][CH2:13][CH3:14])[C:10](=[O:15])[NH:9][C:8](=[O:16])[C:7]=1[NH:1][CH:17]=[O:19]

参加物

6

反応物 3

HCID 284Formic AcidHCID 1045626-Amino-1-propyluracilHCID 23668193Sodium Nitrite

生成物 1

HCID 159313106-amino-5-formamido-1-propyl-2,4-(1H,3H)-pyrimidinedione

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 962Water溶媒

実験手順

Sodium nitrite (127 kg) was dissolved in water and added to suspension of 6-amino-1-propyl-2,4-(1H,3H)-pyrimidinedione (300 kg) in formic acid (1 400 kg). Pt/C 5 % was added and the reaction mixture was heated to 40°-80° C. The catalyst was filtered off, formic acid was distilled off and ethanol (870 kg) was added. The product was precipitated by cooling and isolated by centrifugation, washed with ethanol/water and used directly in Example 2.

後処理

  1. temperaturethe reaction mixture was heated to 40°-80° C
  2. filtrationThe catalyst was filtered off
  3. distillationformic acid was distilled off
  4. additionethanol (870 kg) was added
  5. customThe product was precipitated
  6. temperatureby cooling
  7. customisolated by centrifugation
  8. washwashed with ethanol/water

出典と根拠

ORDレコード
ord-c989df1d00ac4daeaf6f9d8b1d9d8be3
出典データセット
uspto-grants-1988_10
特許番号
US04777255

関連ノート

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