Thiophenol → 3-Thiophenoxymethyl-5-t-octylcatechol

HRID 867984

反応式

HRID 867984 の反応式
O1CCN([CH2:7][C:8]2[CH:14]=[C:13]([C:15]([CH2:18][C:19]([CH3:22])([CH3:21])[CH3:20])([CH3:17])[CH3:16])[CH:12]=[C:10]([OH:11])[C:9]=2[OH:23])CC1.[C:24]1([SH:30])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>CN(C)C=O.C(OCC)C>[S:30]([CH2:7][C:8]1[CH:14]=[C:13]([C:15]([CH2:18][C:19]([CH3:20])([CH3:21])[CH3:22])([CH3:16])[CH3:17])[CH:12]=[C:10]([OH:11])[C:9]=1[OH:23])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

参加物

5

反応物 2

HCID 7969ThiophenolHCID 2231903-Morpholinomethyl-5-t-octylcatechol

生成物 1

HCID 151178453-Thiophenoxymethyl-5-t-octylcatechol

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6228Dimethylformamide溶媒

反応条件

温度
25 °C

実験手順

A suspension of 3-morpholinomethyl-5-t-octylcatechol (564 g, 1.76 mole) and 193.4 g (1.76 mole) benzenethiol in 0.8 liter dimethylformamide was kept at 130° C. under a nitrogen atmosphere for 20 hours. The reaction mixture was cooled to 25° C. and diluted with 3,000 ml diethyl ether. The resulting solution was washed in turn with 3×1,000 ml water, 500 ml 10% hydrochloric acid, 500 ml water and 500 ml brine. The washed solution was dried over anhydrous magnesium sulfate and evaporated in vacuo to a yellow oil (548.9 g, 91% yield) of the title compound.

後処理

  1. washThe resulting solution was washed in turn with 3×1,000 ml water, 500 ml 10% hydrochloric acid, 500 ml water and 500 ml brine
  2. dry with materialThe washed solution was dried over anhydrous magnesium sulfate

出典と根拠

ORDレコード
ord-807cf098570340e593a8413f9e046dce
出典データセット
uspto-grants-1988_10
特許番号
US04777270

関連ノート

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