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Water → 1-benzylazetidine-3,3-dicarboxylic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | [1-Benzyl-3-(hydroxymethyl)azetidin-3-YL]methanol | HCID 20164320 | — |
| 触媒 | Nickel Sulfate | HCID 24586 | — |
| 生成物 | 1-benzylazetidine-3,3-dicarboxylic Acid | HCID 11310885 | — |
反応手順
Bromine (10.6 g) was slowly added at 20° C. over 8 hours to a mixture of N-benzyl-3,3-bis(hydroxymethyl)azetidine (2.1 g) in water (50 ml) containing sodium hydroxide (9.3 g) and nickel chloride 6.0 aq. (1.5 g). After stirring overnight, the green precipitate of nickel hydroxide was filtered off, and the filtrate evaporated to dryness. The residue was boiled in ethanol, and the insoluble material (desired product as sodium salt and sodium bromide) separated and worked up to yield the N-benzyl-azetidine-3,3-dicarboxylic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04778577 |
| 出典データセット | uspto-grants-1988_10 |
| ORD ID | ord-838be3ff0e684522a9c780bbcef962f4 |
| 出典メモ | uspto-grants-1988_10 |