Piperidine → 2-Propenoic acid,2-cyano-3-(3-pyridinyl)-
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=O)[CH:2]=1.[C:9]([CH2:11][C:12]([OH:14])=[O:13])#[N:10].N1CCCCC1>C(O)C>[C:9]([C:11](=[CH:7][C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)[C:12]([OH:14])=[O:13])#[N:10]参加物
5
反応条件
- 温度
- 100 °C
実験手順
A mixture of 3.8 g of 3-pyridinecarbaldehyde, 3.0 g of cyanoacetic acid, 3.0 g of piperidine, and 30 ml of ethanol is stirred at 100° C. for 4 hours. The reaction mixture is concentrated, and 20 ml of water is added. The mixture is adjusted to pH 4.5 with 10% hydrochloric acid. The resulting precipitate is collected and recrystallized from ethanol to give 3.8 g of the title compound, m.p. 223°-227° C.
後処理
- concentrationThe reaction mixture is concentrated
- addition20 ml of water is added
- customThe resulting precipitate is collected
- customrecrystallized from ethanol
出典と根拠
- ORDレコード
- ord-5f6dddd4f7944301b9d4a14d11d22f24
- 出典データセット
- uspto-grants-1988_10
- 特許番号
- US04778796
反応ノート
読み込み中…