Hydrochloric Acid → 3'-Chloro-4'-octyloxy-4-biphenylcarboxylic acid

HRID 868473

反応式

HRID 868473 の反応式
[Cl:1]N(Cl)S(C1C=CC(C)=CC=1)(=O)=O.Cl.[CH2:15]([O:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]2[CH:35]=[CH:34][C:33]([C:36]([OH:38])=[O:37])=[CH:32][CH:31]=2)=[CH:26][CH:25]=1)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]>C(O)(=O)C>[Cl:1][C:25]1[CH:26]=[C:27]([C:30]2[CH:35]=[CH:34][C:33]([C:36]([OH:38])=[O:37])=[CH:32][CH:31]=2)[CH:28]=[CH:29][C:24]=1[O:23][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 68056Dichloramine-T2 回HCID 28025564'-(Octyloxy)-[1,1'-biphenyl]-4-carboxylic acid

生成物 1

HCID 147941813'-Chloro-4'-octyloxy-4-biphenylcarboxylic acid収率 128.2%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒3 回

実験手順

N,N-dichloro-p-toluenesulfonamide (hereinafter abbreviated to "dichloramine T") (7.5 g, 0.032 mol) was dissolved in acetic acid (100 ml), followed by adding to the solution, hydrochloric acid (0.4 ml), dropwise adding to the acetic acid solution of dichloramine T, a solution of 4'-octyloxy-4-biphenycarboxylic acid (20 g, 0.063 mol) dissolved in acetic acid (100 ml), refluxing the mixture, allowing it to stand overnight, distilling off acetic acid and filtering off deposited crystals to obtain 3'-chloro-4'-octyloxy-4-biphenylcarboxylic acid (14.8 g) (C-Sc 146° C., Sc 'N' 224° C. and N'-I 232° C.).

後処理

  1. temperaturerefluxing the mixture
  2. distillationdistilling off acetic acid
  3. filtrationfiltering off

出典と根拠

ORDレコード
ord-ecd78c79eb6c4881be2212cea45e9e26
出典データセット
uspto-grants-1988_10
特許番号
US04780242

関連ノート

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