Hydrochloric Acid → 3-Chloro-4-hydroxy-benzoic acid 2-methyl-butyl ester

HRID 868476

反応式

HRID 868476 の反応式
ClNCl.[ClH:4].[CH3:5][CH:6]([CH2:18][CH3:19])[CH2:7][O:8][C:9](=[O:17])[C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1>C(O)(=O)C>[CH3:5][CH:6]([CH2:18][CH3:19])[CH2:7][O:8][C:9](=[O:17])[C:10]1[CH:11]=[CH:12][C:13]([OH:16])=[C:14]([Cl:4])[CH:15]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 76939ChlorimideHCID 13530949Benzoic acid, 4-hydroxy-, 2-methylbutyl ester

生成物 1

HCID 230416823-Chloro-4-hydroxy-benzoic acid 2-methyl-butyl ester

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

On the other hand, dichloroamine T (28.0 g, 0.12 mol) was dissolved in acetic acid (450 ml), and hydrochloric acid (1.5 ml) was added. The resulting solution was dropwise added to a solution of the above p-hydroxybenzoic acid 2-methyl-butyl ester (50 g, 0.24 mol) dissolved in acetic acid (450 ml), followed by refluxing the mixture, allowing to stand overnight, distilling off acetic acid and filtering off deposited crystals to obtain 3-chloro-4-hydroxy-benzoic acid 2-methyl-butyl ester (42 g) (b.p. 135°~138° C./4 mmHg).

後処理

  1. temperatureby refluxing the mixture
  2. distillationdistilling off acetic acid
  3. filtrationfiltering off

出典と根拠

ORDレコード
ord-d758b38bf38540e5843d0f8742dd452f
出典データセット
uspto-grants-1988_10
特許番号
US04780242

関連ノート

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