Cyclopentylamine → N-cyclopentyl-1-propyl[1,2,4]triazolo[4,3-a]quinoxalin-4-amine

HRID 868517

反応式

HRID 868517 の反応式
Cl[C:2]1[C:3]2[N:4]([C:12]([CH2:15][CH2:16][CH3:17])=[N:13][N:14]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[CH:18]1([NH2:23])[CH2:22][CH2:21][CH2:20][CH2:19]1>CN(C=O)C>[CH:18]1([NH:23][C:2]2[C:3]3[N:4]([C:12]([CH2:15][CH2:16][CH3:17])=[N:13][N:14]=3)[C:5]3[C:10]([N:11]=2)=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH2:22][CH2:21][CH2:20][CH2:19]1

参加物

4

反応物 2

HCID 2906CyclopentylamineHCID 133857074-Chloro-1-propyl[1,2,4]triazolo[4,3-a]quinoxaline

生成物 1

HCID 14280611N-cyclopentyl-1-propyl[1,2,4]triazolo[4,3-a]quinoxalin-4-amine収率 82.9%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A reaction mixture of 4-chloro-1-propyl[1,2,4]triazolo[4,3-a]quinoxaline (1.0 g; 0.004 mole) and cyclopentanamine (1.0 g; 0.012 mole) in 15 ml of DMF was stirred at room temperature for 20 hours. The precipitated solid was filtered, washed with ethanol, and dried affording 0.98 g (82%) of N-cyclopentyl-1-propyl[1,2,4]triazolo[4,3-a]quinoxalin-4-amine having a mp of 186°-188° C.

後処理

  1. filtrationThe precipitated solid was filtered
  2. washwashed with ethanol
  3. customdried

出典と根拠

ORDレコード
ord-f2ad039bb3c44e1e802c1daac48e2ee6
出典データセット
uspto-grants-1988_10
特許番号
US04780464

関連ノート

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