alpha-Aminoisobutyryl-alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride → alpha-Aminoisobutyryl-alpha-L-aspartyl-L-phenylalanine methyl ester

HRID 868655ノート

反応式

HRID 868655 の反応式
Cl.[CH3:2][O:3][C:4](=[O:28])[C@H:5]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[NH:6][C:7](=[O:20])[C@:8]([NH2:19])([CH2:15][C:16](=[O:18])[OH:17])[NH:9][C:10](=[O:14])[CH:11]([CH3:13])[CH3:12]>O>[CH3:2][O:3][C:4](=[O:28])[C@H:5]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[NH:6][C:7](=[O:20])[C@:8]([NH2:19])([CH2:15][C:16](=[O:17])[OH:18])[NH:9][C:10](=[O:14])[CH:11]([CH3:13])[CH3:12]

参加物

3

反応物 1

HCID 86742496alpha-Aminoisobutyryl-alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride

生成物 1

HCID 86742497alpha-Aminoisobutyryl-alpha-L-aspartyl-L-phenylalanine methyl ester収率 85.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 1.8 g α-aminoisobutyryl-α-L-aspartyl-L-phenylalanine methyl ester hydrochloride in 50 ml water was allowed to pass through a column (50 ml) packed with a weakly basic anion-exchange resin (Dow Chemical Co., "IRA-68"), and the resin was washed with 100 ml water. The washings were added to the effluent, and the combined solution was concentrated under reduced pressure, giving 1.4 g of white powder. M.p.: 168°-170° C.

後処理

  1. washthe resin was washed with 100 ml water
  2. additionThe washings were added to the effluent, and the combined solution
  3. concentrationwas concentrated under reduced pressure

出典と根拠

ORDレコード
ord-e239165540134d59bfa22ec56a6f3d39
出典データセット
uspto-grants-1988_10
特許番号
US04780528

反応ノート

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