1-Butanol → Butyl pyruvate

HRID 868772

反応式

HRID 868772 の反応式
[C:1]([OH:6])(=[O:5])[C:2]([CH3:4])=[O:3].[CH2:7](O)[CH2:8][CH2:9][CH3:10]>O.C1(C)C=CC(S(O)(=O)=O)=CC=1.C1(C)C=CC=CC=1>[C:1]([O:6][CH2:7][CH2:8][CH2:9][CH3:10])(=[O:5])[C:2]([CH3:4])=[O:3]

参加物

5

反応物 2

HCID 2631-ButanolHCID 1060Pyruvic Acid

生成物 1

HCID 523883Butyl pyruvate収率 70.1%

試薬・触媒・溶媒 2

HCID 521998p-Toluenesulfonic acid monohydrate触媒HCID 1140Toluene溶媒

反応条件

温度
25 °C

実験手順

First, a toluene (1 L) solution of pyruvic acid (440 g, 5.0 mol), n-butanol (371 g, 5.0 mol) and p-toluenesulfonic acid monohydrate (2.5 g) was heated and refluxed for 16 hours while removing water under a nitrogen gas stream, whereby a first reaction solution was obtained. Next, the first reaction solution was cooled to room temperature (25° C.). Thereafter, toluene was removed under reduced pressure (40 mmHg) using an evaporator, and the residue was purified by reduced pressure distillation (40 mmHg, 93 to 100° C.), whereby butyl pyruvate (505 g, yield 70%) was obtained.

後処理

  1. temperaturerefluxed for 16 hours
  2. customwhile removing water under a nitrogen gas stream, whereby a first reaction solution
  3. customwas obtained
  4. customThereafter, toluene was removed under reduced pressure (40 mmHg)
  5. customan evaporator
  6. distillationthe residue was purified by reduced pressure distillation (40 mmHg, 93 to 100° C.)

出典と根拠

ORDレコード
ord-e3f4b785506842d7aa2cf4bb89d386b6
出典データセット
uspto-grants-2015_03
特許番号
US08968975B2

関連ノート

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