Benzyl Bromide → 1-benzyl-5-fluoro-3-iodo-1H-indazole

反応式

[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[I:11].[CH2:12](Br)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:12]([N:7]1[C:8]2[C:4](=[CH:3][C:2]([F:1])=[CH:10][CH:9]=2)[C:5]([I:11])=[N:6]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

反応物 2

HCID 7498Benzyl Bromide

HCID 178505475HCID 178505475、化合物

生成物 1

HCID 867231431-benzyl-5-fluoro-3-iodo-1H-indazole収率 75%

実験手順

The title compound was prepared in 75% yield from 5-fluoro-3-iodo-indazole and benzyl bromide according to the general procedure for Preparation 10A. The minor isomer was not isolated or characterized. 1H NMR (400 MHz, CDCl3): δ 5.59 (2H, s), 7.11-7.21 (5H, m), 7.23-7.31 (3H, m).

後処理

customThe minor isomer was not isolated

出典と根拠

ORDレコード: ord-f70d12814ffb4b8894c45f1dd3a8856a
出典データセット: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08969343B2

反応ノート

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