(3-Phenyl-5-isoxazolyl)methanol → 3-Phenyl-1,2-oxazole-5-carbaldehyde

HRID 868924

反応式

HRID 868924 の反応式
[C:1]1([C:7]2[CH:11]=[C:10]([CH2:12][OH:13])[O:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>C(Cl)Cl>[C:1]1([C:7]2[CH:11]=[C:10]([CH:12]=[O:13])[O:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 2763417(3-Phenyl-5-isoxazolyl)methanolHCID 178418287HCID 178418287、化合物

生成物 1

HCID 113672673-Phenyl-1,2-oxazole-5-carbaldehyde収率 67.9%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To (3-phenylisoxazol-5-yl)methanol (0.9 g, 5.1 mmol) in DCM (10 mL) was added pyridinium chlorochromate (PCC) (2.1 g, 10.2 mmol) and the mixture was stirred at room temperature for 2 hours. The reaction was quenched with water, extracted with EtOAc and dried over anhydrous sodium sulfate. The solution was then concentrated under vacuum to give 3-phenylisoxazole-5-carbaldehyde as a light yellow solid (600 mg).

後処理

  1. customThe reaction was quenched with water
  2. extractionextracted with EtOAc
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationThe solution was then concentrated under vacuum

出典と根拠

ORDレコード
ord-3f01702367b44dc4b6811f1ac489c814
出典データセット
uspto-grants-2015_03
特許番号
US08969349B2

関連ノート

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