Ethanol → Ethyl 3-Aminoisonicotinate

HRID 868957

反応式

HRID 868957 の反応式
[NH2:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(=O)(=O)(O)O.[CH2:16](O)[CH3:17]>C1(C)C=CC=CC=1>[NH2:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH2:16][CH3:17])=[O:5]

参加物

5

反応物 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 4595313-Aminoisonicotinic acid

生成物 1

HCID 2736365Ethyl 3-Aminoisonicotinate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To an ice-cold suspension of 3-aminoisonicotinic acid (8 g, 58 mmol) in ethanol (36 mL) and toluene (36 mL) was added concentrated sulfuric acid (6.4 mL), and the mixture was stirred for 24 h. The solvents were removed under reduced pressure, the residue was dissolved in water, and the solution was adjusted to pH 8 with concentrated ammonium hydroxide to give ethyl 3-aminoisonicotinate (6.5 g). MS (ESI): m/z 167 [M+H]+.

後処理

  1. customThe solvents were removed under reduced pressure
  2. dissolutionthe residue was dissolved in water

出典と根拠

ORDレコード
ord-5af5714a24524f9b806dd5e0a82c303d
出典データセット
uspto-grants-2015_03
特許番号
US08969349B2

関連ノート

読み込み中…