Ethanol → Ethyl 3-Aminoisonicotinate
反応式
[NH2:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(=O)(=O)(O)O.[CH2:16](O)[CH3:17]>C1(C)C=CC=CC=1>[NH2:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([O:6][CH2:16][CH3:17])=[O:5]参加物
5
実験手順
To an ice-cold suspension of 3-aminoisonicotinic acid (8 g, 58 mmol) in ethanol (36 mL) and toluene (36 mL) was added concentrated sulfuric acid (6.4 mL), and the mixture was stirred for 24 h. The solvents were removed under reduced pressure, the residue was dissolved in water, and the solution was adjusted to pH 8 with concentrated ammonium hydroxide to give ethyl 3-aminoisonicotinate (6.5 g). MS (ESI): m/z 167 [M+H]+.
後処理
- customThe solvents were removed under reduced pressure
- dissolutionthe residue was dissolved in water
出典と根拠
- ORDレコード
- ord-5af5714a24524f9b806dd5e0a82c303d
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08969349B2
反応ノート
読み込み中…