Hydrochloric Acid → HCID 131732524、化合物
反応式
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[CH:5][C:6]([NH:9][C@H:10]2[C@@H:15]3[CH2:16][C@@H:12]([CH2:13][N:14]3C(OC(C)(C)C)=O)[CH2:11]2)=[N:7][CH:8]=1.Cl>CCOC(C)=O.O1CCOCC1>[F:25][C:2]([F:1])([F:24])[C:3]1[CH:4]=[CH:5][C:6]([NH:9][C@H:10]2[C@@H:15]3[CH2:16][C@@H:12]([CH2:13][NH:14]3)[CH2:11]2)=[N:7][CH:8]=1参加物
5
実験手順
To the title compound of step A (198 mg, 0.554 mmol) in EtOAc (3 mL) was added 4M HCl in dioxane (14 mL). After 1 h, the reaction was concentrated to give the title compound of step B (183 mg), which was used without further purification. MS (ESI) mass calcd. for C12H14F3N3, 257.1. m/z found 258.1 [M+H]+.
後処理
- concentrationthe reaction was concentrated
出典と根拠
- ORDレコード
- ord-6995abb364f74b478038e0e5f51c6918
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08969352B2
反応ノート
読み込み中…