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Acetonitrile → 2-[3-(3-Thieno[2,3-d]isoxazol-3-yl-phenoxy)-propyl]-1,2,3,4-tetrahydroisoquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | 1,2,3,4-Tetrahydroisoquinoline | HCID 7046 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-[3-(3-Bromo-propoxy)phenyl]-thieno[2,3-d]isoxazole | HCID 21983559 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-[3-(3-Thieno[2,3-d]isoxazol-3-yl-phenoxy)-propyl]-1,2,3,4-tetrahydroisoquinoline | HCID 21983568 | — |
反応手順
The title compound is prepared from 3-[3-(3-bromo-propoxy)-phenyl]-thieno[2,3-d]isoxazole, potassium carbonate, 1,2,3,4-tetrahydroisoquinoline and acetonitrile essentially as described above in example 48 except that the crude product is dissolve in DCM and purified by using a step gradient of 50% ethyl acetate in heptane, to 100% ethyl acetate. Purity by LC/MS (APCI)=96%, [M+H]+=391.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07091199B1 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-f77827b82f184b44a8fecc9f72a1fa72 |
| 出典メモ | uspto-grants-2006_08 |