Water → HCID 86722240、化合物

HRID 869391ノート

反応式

HRID 869391 の反応式
[NH2:1][C:2]1[C:6]2[C:7]([Cl:13])=[C:8]([O:11][CH3:12])[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[C:14](=[O:25])[CH:15]=[CH:16][C:17]1[N:18]=[C:19]([CH:22]([CH3:24])[CH3:23])[S:20][CH:21]=1.O>CC(O)=O.OP(O)(O)=O>[Cl:13][C:7]1[C:6]2[C:2]3[NH:1][CH:16]([C:17]4[N:18]=[C:19]([CH:22]([CH3:23])[CH3:24])[S:20][CH:21]=4)[CH2:15][C:14](=[O:25])[C:3]=3[O:4][C:5]=2[CH:10]=[CH:9][C:8]=1[O:11][CH3:12]

参加物

5

反応物 2

HCID 962WaterHCID 86722239HCID 86722239、化合物

生成物 1

HCID 86722240HCID 86722240、化合物収率 108.4%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 1004Phosphoric Acid溶媒

実験手順

10A (9.96 g, 26.43 mmol) was dissolved in AcOH (50 mL) and H3PO4 (50 mL). The solution was refluxed for 2 hours. TLC monitored the reaction. After the reaction completed, the reaction mixture was cooled to room temperature and poured into water (200 mL) The brown precipitates were collected by filtration and dried to give product 10B (10.8 g), which was used for the next step directly.

後処理

  1. temperatureThe solution was refluxed for 2 hours
  2. customthe reaction
  3. custombrown precipitates
  4. filtrationwere collected by filtration
  5. customdried

出典と根拠

ORDレコード
ord-be5b8a68658446a68a3c0d5d799e4af6
出典データセット
uspto-grants-2015_03
特許番号
US08969373B2

反応ノート

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