Phosphorus oxychloride → HCID 86722242、化合物

HRID 869393ノート

反応式

HRID 869393 の反応式
O[C:2]1[CH:7]=[C:6]([C:8]2[N:9]=[C:10]([CH:13]([CH3:15])[CH3:14])[S:11][CH:12]=2)[N:5]=[C:4]2[C:16]3[C:22]([Cl:23])=[C:21]([O:24][CH3:25])[CH:20]=[CH:19][C:17]=3[O:18][C:3]=12.O=P(Cl)(Cl)[Cl:28]>>[Cl:28][C:2]1[CH:7]=[C:6]([C:8]2[N:9]=[C:10]([CH:13]([CH3:15])[CH3:14])[S:11][CH:12]=2)[N:5]=[C:4]2[C:16]3[C:22]([Cl:23])=[C:21]([O:24][CH3:25])[CH:20]=[CH:19][C:17]=3[O:18][C:3]=12

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 178488262HCID 178488262、化合物

生成物 1

HCID 86722242HCID 86722242、化合物

実験手順

The crude 10C (8.75 g, 23.34 mmol) was added to POCl3 (200 mL) The mixture was refluxed for 2 hours. TLC monitored the reaction. After the reaction completed, POCl3 was evaporated under reduced pressure. The residue was poured into crushed ice under stirring. The yellow solids were collected by filtration and purified by flash chromatography to give product M10 (0.66 g).

後処理

  1. temperaturewas refluxed for 2 hours
  2. customthe reaction
  3. customPOCl3 was evaporated under reduced pressure
  4. additionThe residue was poured
  5. custominto crushed ice
  6. filtrationThe yellow solids were collected by filtration
  7. custompurified by flash chromatography
  8. customto give product M10 (0.66 g)

出典と根拠

ORDレコード
ord-a8a8e91967864ef4b21bc3073a0eac08
出典データセット
uspto-grants-2015_03
特許番号
US08969373B2

反応ノート

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