Acetic Anhydride → HCID 86722248、化合物

HRID 869403ノート

反応式

HRID 869403 の反応式
[Br:1][C:2]1[C:10]([OH:11])=[CH:9][CH:8]=[C:7]([OH:12])[C:3]=1[CH:4]=[N:5]O.[C:13]([O-:16])(=O)[CH3:14].[Na+].[CH3:18][C:19](OC(C)=O)=[O:20]>>[Br:1][C:2]1[C:3]([C:4]#[N:5])=[C:7]([O:12][C:19]([CH3:18])=[O:20])[CH:8]=[CH:9][C:10]=1[O:11][C:13]([CH3:14])=[O:16]

参加物

4

反応物 3

HCID 7918Acetic AnhydrideHCID 517045Sodium AcetateHCID 136348391HCID 136348391、化合物

生成物 1

HCID 86722248HCID 86722248、化合物収率 69.1%

実験手順

A mixture of 12B (45 g, 0.193 mol) and sodium acetate (3 g) in Ac2O (200 mL) was heated to reflux overnight. The reaction mixture was evaporated under reduced pressure to remove Ac2O. The residue was poured into water and stirred for 1 hour. The precipitated solids were collected by filtration and dried to give 12C (40 g, 69.1% yield).

後処理

  1. temperaturewas heated
  2. temperatureto reflux overnight
  3. customThe reaction mixture was evaporated under reduced pressure
  4. customto remove Ac2O
  5. additionThe residue was poured into water
  6. filtrationThe precipitated solids were collected by filtration
  7. customdried

出典と根拠

ORDレコード
ord-4690db8eb6fb4922a5ce28c8b3ae7e17
出典データセット
uspto-grants-2015_03
特許番号
US08969373B2

反応ノート

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