Hydrochloric Acid → HCID 86722249、化合物

HRID 869404ノート

反応式

HRID 869404 の反応式
[Br:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([O:10]C(C)=O)[CH:5]=[CH:4][C:3]=1[O:14][C:15]([CH3:17])=[O:16].CO.C([O-])([O-])=O.[K+].[K+].Cl>ClCCl>[C:15]([O:14][C:3]1[CH:4]=[CH:5][C:6]([OH:10])=[C:7]([C:8]#[N:9])[C:2]=1[Br:1])(=[O:16])[CH3:17]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 11430Potassium CarbonateHCID 86722248HCID 86722248、化合物

生成物 1

HCID 86722249HCID 86722249、化合物収率 62.5%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

12C (15 g, 0.05 mol) was added to MeOH (52 ml) and dichloromethane (52 mL). To the mixture was added K2CO3 (7 g, 0.05 mol) in batches at room temperature. The reaction mixture was stirred overnight at room temperture, then neutralized with diluted hydrochloric acid to pH=6˜7, extracted with dichloromethane, dried over anhydrous Na2SO4 and concentrated to give 12D (8 g, 62.1% yield).

後処理

  1. extractionextracted with dichloromethane
  2. dry with materialdried over anhydrous Na2SO4
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-079f798c7ac44463a7e558471894e8f8
出典データセット
uspto-grants-2015_03
特許番号
US08969373B2

反応ノート

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