3-Aminopyridine → Ethyl 2-cyano-3-(pyridin-3-ylamino)acrylate

HRID 869445ノート

反応式

HRID 869445 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH2:7])[CH:2]=1.[C:8](/[C:10](=[CH:16]\OCC)/[C:11]([O:13][CH2:14][CH3:15])=[O:12])#[N:9]>C1(C)C=CC=CC=1>[C:8]([C:10](=[CH:16][NH:7][C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)[C:11]([O:13][CH2:14][CH3:15])=[O:12])#[N:9]

参加物

4

反応物 2

HCID 100093-AminopyridineHCID 1715183Ethyl 2-cyano-3-ethoxyacrylate

生成物 1

HCID 71226778Ethyl 2-cyano-3-(pyridin-3-ylamino)acrylate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of pyridin-3-amine (C-1) (10.0 g, 106.3 mmol, 1.0 eq) and (E)-ethyl 2-cyano-3-ethoxyacrylate (C-2) (21.5 g, 127 mmol, 1.2 eq) in toluene (40 mL) is stirred at reflux under argon for 5 h and then allowed to cool to RT. The precipitate is collected by filtration, rinsed with a mixture of petroether and ethyl acetate (v/v=2:1, 3×10 mL), and then dried in vacuo to afford the product, ethyl 2-cyano-3-(pyridin-3-ylamino)acrylate (C-3).

後処理

  1. temperatureat reflux under argon for 5 h
  2. filtrationThe precipitate is collected by filtration
  3. washrinsed with a mixture of petroether and ethyl acetate (v/v=2:1, 3×10 mL)
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-3b1dd2a6af12464b994ad6d06c885d6d
出典データセット
uspto-grants-2015_03
特許番号
US08969363B2

反応ノート

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