Triacetoxyperiodinane → Imidazo[1,2-b]pyridazine-3-carbaldehyde

HRID 869478ノート

反応式

HRID 869478 の反応式
[N:1]1[CH:2]=[C:3]([CH2:10][OH:11])[N:4]2[C:9]=1[CH:8]=[CH:7][CH:6]=[N:5]2.CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O>C(Cl)Cl>[N:1]1[CH:2]=[C:3]([CH:10]=[O:11])[N:4]2[C:9]=1[CH:8]=[CH:7][CH:6]=[N:5]2

参加物

4

反応物 2

HCID 159087TriacetoxyperiodinaneHCID 71744071HCID 71744071、化合物

生成物 1

HCID 45083595Imidazo[1,2-b]pyridazine-3-carbaldehyde収率 90.7%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of imidazo[1,2-b]pyridazin-3-ylmethanol (45 mg, 0.3 mmol) and Dess-Martin periodinane (130 mg, 0.3 mmol) in anhydrous DCM (5 mL) were stirred at RT overnight. The reaction mixture was quenched with water (5 mL). The organic layer was separated, dried over MgSO4 and filtered. The filtrate was concentrated in vacuo to afford imidazo[1,2-b]pyridazine-3-carbaldehyde (40 mg, 90.7% yield).

後処理

  1. customThe reaction mixture was quenched with water (5 mL)
  2. customThe organic layer was separated
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-4cf7c16a8cc64a238b23a4b4c272371b
出典データセット
uspto-grants-2015_03
特許番号
US08969363B2

反応ノート

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