2-(Pyrrolidin-1-yl)-1H-benzo[d]imidazole → (E)-2-(3-fluoro-8-{[2-(pyrrolidin-1-yl)-1H-benzo[d]imidazol-1-yl]methyl}dibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile

HRID 869551

反応式

HRID 869551 の反応式
[N:1]1([C:6]2[NH:10][C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[N:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.Br[CH2:16][C:17]1[CH:36]=[CH:35][C:20]2/[C:21](=[C:31](/[CH3:34])\[C:32]#[N:33])/[C:22]3[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:23]=3[O:24][CH2:25][C:19]=2[CH:18]=1>>[F:30][C:27]1[CH:28]=[CH:29][C:22]2=[C:23]([CH:26]=1)[O:24][CH2:25][C:19]1[CH:18]=[C:17]([CH2:16][N:10]3[C:9]4[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=4[N:7]=[C:6]3[N:1]3[CH2:5][CH2:4][CH2:3][CH2:2]3)[CH:36]=[CH:35][C:20]=1/[C:21]/2=[C:31](/[CH3:34])\[C:32]#[N:33]

参加物

3

反応物 2

HCID 69918962-(Pyrrolidin-1-yl)-1H-benzo[d]imidazoleHCID 86721333(E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile

生成物 1

HCID 86721384(E)-2-(3-fluoro-8-{[2-(pyrrolidin-1-yl)-1H-benzo[d]imidazol-1-yl]methyl}dibenzo[b,e]oxepin-11(6H)-ylidene)propanenitrile収率 91%

実験手順

Using commercially available 2-(pyrrolidin-1-yl)-1H-benzo[d]imidazole (63 mg, 0.34 mmol) and (E)-2-[8-(bromomethyl)-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (120 mg, 0.34 mmol) obtained in Reference Example 1, and in the same manner as in Reference Example 1A, the title compound (141 mg, 91%) was obtained.

後処理

  1. customobtained in Reference Example 1

出典と根拠

ORDレコード
ord-01b709a5206641059ab6bcd00ad1c223
出典データセット
uspto-grants-2015_03
特許番号
US08969345B2

関連ノート

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