2-cyclopropyl-1H-1,3-benzodiazole → (E)-2-cyclopropyl-2-{8-[(2-cyclopropyl-1H-benzo[d]imidazol-1-yl)methyl]-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene)acetonitrile

HRID 869556ノート

反応式

HRID 869556 の反応式
[CH:1]1([C:4]2[NH:8][C:7]3[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=3[N:5]=2)[CH2:3][CH2:2]1.Br[CH2:14][C:15]1[CH:36]=[CH:35][C:18]2/[C:19](=[C:29](/[CH:32]3[CH2:34][CH2:33]3)\[C:30]#[N:31])/[C:20]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][C:21]=3[O:22][CH2:23][C:17]=2[CH:16]=1>>[CH:32]1(/[C:29](=[C:19]2\[C:20]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][C:21]=3[O:22][CH2:23][C:17]3[CH:16]=[C:15]([CH2:14][N:8]4[C:7]5[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=5[N:5]=[C:4]4[CH:1]4[CH2:3][CH2:2]4)[CH:36]=[CH:35][C:18]\2=3)/[C:30]#[N:31])[CH2:34][CH2:33]1

参加物

3

反応物 2

HCID 10844192-cyclopropyl-1H-1,3-benzodiazoleHCID 86721388(E)-2-(8-bromomethyl-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene)-2-cyclopropylacetonitrile

生成物 1

HCID 86721389(E)-2-cyclopropyl-2-{8-[(2-cyclopropyl-1H-benzo[d]imidazol-1-yl)methyl]-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene)acetonitrile収率 93%

実験手順

Using 2-cyclopropyl-1H-benzo[d]imidazole (European Journal of Organic Chemistry, 2000, p 1229, 58 mg, 0.33 mmol) and (E)-2-(8-bromomethyl-3-fluorodibenzo[b,e]oxepin-11(6H)-ylidene)-2-cyclopropylacetonitrile (120 mg, 0.31 mmol) obtained in Reference Example 6, and in the same manner as in Reference Example 1A, the title compound (133 mg, 93%) was obtained.

後処理

  1. customobtained in Reference Example 6

出典と根拠

ORDレコード
ord-e84a5c4544914eeeaaae9a742f8fa1e5
出典データセット
uspto-grants-2015_03
特許番号
US08969345B2

反応ノート

読み込み中…