2-Propyl-1H-benzimidazole → (E)-2-{1,3-difluoro-8-[(2-propyl-1H-benzo[d]imidazol-1-yl)methyl]dibenzo[b,e]oxepin-11(6H)-ylidene}propanenitrile

HRID 869559ノート

反応式

HRID 869559 の反応式
[CH2:1]([C:4]1[NH:8][C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[N:5]=1)[CH2:2][CH3:3].Br[CH2:14][C:15]1[CH:35]=[CH:34][C:18]2/[C:19](=[C:30](/[CH3:33])\[C:31]#[N:32])/[C:20]3[C:27]([F:28])=[CH:26][C:25]([F:29])=[CH:24][C:21]=3[O:22][CH2:23][C:17]=2[CH:16]=1>>[F:28][C:27]1[C:20]2/[C:19](=[C:30](\[CH3:33])/[C:31]#[N:32])/[C:18]3[CH:34]=[CH:35][C:15]([CH2:14][N:8]4[C:7]5[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=5[N:5]=[C:4]4[CH2:1][CH2:2][CH3:3])=[CH:16][C:17]=3[CH2:23][O:22][C:21]=2[CH:24]=[C:25]([F:29])[CH:26]=1

参加物

3

反応物 2

HCID 216242-Propyl-1H-benzimidazoleHCID 86721394(E)-2-[8-(bromomethyl)-1,3-difluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile

生成物 1

HCID 86721393(E)-2-{1,3-difluoro-8-[(2-propyl-1H-benzo[d]imidazol-1-yl)methyl]dibenzo[b,e]oxepin-11(6H)-ylidene}propanenitrile収率 97%

実験手順

Using 2-propyl-1H-benzo[d]imidazole (Synthetic Communication, 2002, vol. 32, p 3703; 67 mg, 0.42 mmol) and (E)-2-[8-(bromomethyl)-1,3-difluorodibenzo[b,e]oxepin-11(6H)-ylidene]propanenitrile (160 mg, 0.43 mmol) obtained in Reference Example 2, and in the same manner as in Reference Example 1A, the title compound (184 mg, 97%) was obtained.

後処理

  1. customobtained in Reference Example 2

出典と根拠

ORDレコード
ord-6ad84774950f401386415474c30a5feb
出典データセット
uspto-grants-2015_03
特許番号
US08969345B2

反応ノート

読み込み中…